Brain Tumors

Each year, more than 90,000 Americans will face the life-changing diagnosis of a brain tumor. At the forefront of treating this condition is BOBÌåÓý, which performs approximately 600 brain tumor operations annually, making it one of the highest-volume academic medical centers in the country.
Our distinguished researchers and their teams collaborate daily with physicians who have dedicated their careers to finding a cure for brain cancer. Together, they use the latest molecular, biological, medical and surgical techniques to understand the fundamental causes of brain tumors and develop new treatment methods.
BOBÌåÓý: Pioneers for brain tumor treatments and therapies
Watch how Duane Mitchell, MD, PhD, and his team at the Preston A. Wells Jr. Center for Brain Tumor Therapy at the University of Florida have developed one of the most comprehensive clinical and research centers for advancing brain tumor treatment and discovering novel approaches.

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What is a brain tumor?
Brain tumors are characterized by abnormal cell growth in or around your brain. A mass can be small or large and can either be a benign tumor (noncancerous) or a malignant tumor (cancerous).
Brain function can be affected if they grow large enough to pressure surrounding structures like brain tissue, nerves and blood vessels. Malignant brain tumors � also called brain cancers � tend to grow quickly, while benign brain tumors tend to grow slowly.
Understanding the types, symptoms, causes and treatment options is crucial for effective management. BOBÌåÓý offers advanced, patient-centered care for adults and children with brain tumors.


We are proud to care for patients at BOBÌåÓý Shands Hospital, ranked as one of the nation's top hospitals for neurology and neurosurgery by U.S. News & World Report.
Types of brain tumors
There are more than 120 different types, and they can be classified in many ways, one of which is based on their origin and behavior:
- Primary brain tumor: Originates within the brain. Examples include a glioma, meningioma or pituitary adenoma.
- Metastatic brain tumor: Spreads to the brain from other parts of the body. The most common forms of brain metastases are lung cancer, breast cancer and melanoma.
They can also be classified by histology:
- Glioma: Arises from glial cells, which support and protect neurons. Examples include:
- Astrocytoma
- Ependymoma
- Glioblastoma
- Oligodendroglioma
- Medulloblastoma: Aggressive tumor that commonly occurs in children
- Meningioma: Grows from the protective membranes (meninges) covering the brain
- Pituitary adenoma: Emerges from the pituitary gland, often causing hormonal imbalances depending on the cell type involved
- Schwannoma: Benign tumor that originates from Schwann cells, which insulate nerves
Each type presents unique challenges and requires specialized treatment approaches.
Symptoms
Symptoms vary depending on the tumor's size, location, and growth rate. Common warning signs include:
- Headaches
- Seizures
- Difficulty thinking, speaking, or finding words
- Changes in personality or behavior
- Weakness, numbness, or loss of movement in one part or one side of the body
- Difficulty with balance or dizziness
- Sensory changes like difficulty hearing, difficulty seeing, or loss of smell
- Memory loss
- Confusion in everyday matters or disorientation
- Unexplained nausea or vomiting
- Fatigue or muscle weakness
If you experience persistent or worsening symptoms, please seek medical attention immediately.
Causes and risk factors
The exact cause of most brain tumors remains unknown. However, certain factors may increase risk:
- Genetic predisposition: Family history of brain tumors
- Radiation exposure: Previous radiation therapy to the head
- Age: Some tumors are more common in children, while others occur more frequently in adults
- Cell phones: While some studies in the past have suggested a possible link between cell phone use and increased risk of certain brain tumors, the findings have been inconsistent. Extensive research has not shown categorical proof of this connection. Future research will be needed to determine an increased risk for malignant or benign tumors
Understanding these factors aids in assessing individual risk profiles.
Diagnosis
Accurate diagnosis is essential for effective treatment planning. At BOBÌåÓý, our specialists employ advanced diagnostic tools, including:
- Neurological examinations: To assess reflexes, coordination and sensory functions
- Imaging studies: To visualize tumor location and size using an MRI and CT scan
- Biopsy: To obtain a tissue sample for histological analysis
These methods ensure a comprehensive evaluation of each case.
Treatment options
Our treatment strategies are tailored to the individual's specific tumor type and overall health. BOBÌåÓý’s care options include:
- Surgery: Removing as much of the tumor as possible
- Chemotherapy: Employing drugs to kill or inhibit cancer cells
- Immunotherapy: Boosting the body’s immune system to fight cancer
- Laser interstitial thermal therapy (LITT): Heating and destroying targeted brain tissue using a laser probe as part of a minimally invasive brain surgery
- Optune therapy: Using low-intensity electrical fields to disrupt the division of cancer cells as part of a noninvasive treatment for glioblastoma multiforme
- Radiosurgery: Delivering a large dose of radiation to tumor cells through hundreds of focused radiation beams while sparing normal brain tissue around it
Our multidisciplinary team collaborates to develop personalized treatment plans, ensuring optimal outcomes. For patients, here’s what to expect when you visit BOBÌåÓý.
More reasons to choose BOBÌåÓý
BOBÌåÓý Shands Hospital is nationally recognized for excellence in neurology and neurosurgery, with U.S. News & World Report ranking us among the top hospitals in the country in this field. More specifically, our commitment to leading-edge research, the latest technology and compassionate care makes us leaders in brain tumor treatment.
However, those are just some of the many ways BOBÌåÓý stands out when it comes to brain tumor treatment:
- World-renowned for expertise in neuroanatomy, microsurgery and skull base surgery
- Expertise in endoscopic and other minimally invasive surgical techniques
- UF-patented technology for computer-assisted brain tumor surgery and radiosurgery
- Pediatric tumor expertise
- Complex spine tumor experience
Support services
We understand the emotional and psychological impact of a brain tumor diagnosis. BOBÌåÓý offers comprehensive support services, including counseling, support groups and rehabilitation programs, to assist patients and their families throughout the treatment journey.
Contact us
If you or a loved one is facing a brain tumor diagnosis, trust the experts at BOBÌåÓý. Contact us today to schedule a consultation and learn more about our specialized services.
Brain tumors: From bench to bedside

Patients from 40 states and 3 countries
Our patients have traveled from around the world for our leading-edge programs, clinical trials, personalized treatment.

100+ physicians, researchers, scientists and staff
Our team at BOBÌåÓýÂ includes experts in several specialties.

Over $10 million a year invested in research funding
From immnotherapy to optune therapy, we are leading the country in searching for a cure for brain tumors.
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Clinical Trials: Brain Tumors
BOBÌåÓý research scientists make medicine better every day. They discover new ways to help people by running clinical trials. When you join a clinical trial, you can get advanced medical care. Sometimes years before it's available everywhere. You can also help make medicine better for everyone else. If you'd like to learn more about clinical trials, visit our clinical trials page. Or click one of the links below:
This phase III trial compares memantine to placebo in treating patients with primary central nervous system tumors. Memantine may block receptors (parts of nerve cells) in the brain known to contribute to a decline in cognitive function. Giving�
- Investigator
- Brian Stover
- Status
- Accepting Candidates
- Ages
- 4 Years - 17 Years
- Sexes
- All
The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type 2.0/2.1 for liquid biopsy in subjects with suspected Glioblastoma brain tumors
- Investigator
- Justin D Hilliard
- Status
- Accepting Candidates
- Ages
- 18 Years - 80 Years
- Sexes
- All
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other�
- Investigator
- William Slayton
- Status
- Accepting Candidates
- Ages
- 3 Years - 29 Years
- Sexes
- All
Community and Patient Programs: Brain Tumors
Our community and patient programs provide great value to patients, families and loved ones. People can find support, educational materials, expert consultants and more. In most instances, these programs are offered free of charge.
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Offers a wide variety of music-based therapies from in-room performances to collaborative recording sessions.
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Pain Management - Cancer
Pain management treatment plans for cancer patients.
Calendar Events and Lectures: Brain Tumors
Gainesville, FL 32610
The 4th Annual Cancer Chomp will take place Oct. 25, 2025 at the Cancer and Genetics Research Complex on the beautiful University of Florida campus.�
News and Patient Stories: Brain Tumors
Clinical trials: Advancing care for patients now, and later
May 20, 2025
GAINESVILLE, Fla. � Clinical trials are the foundation of medical advances. They’re essential because they help establish better ways to prevent, diagnose and�
College of Medicine, BOBÌåÓý Cancer Center, +2 more

Walking Toward Hope: Robin Celebrates Milestone on Brain Tumor Journey
Ocala resident Robin Feagle has done something truly remarkable: She completed the American Brain Tumor Association’s February walking challenge, logging 28�

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