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TOPMEDs

  • Status
    Accepting Candidates
  • Age
    40 Years - N/A
  • Sexes
    All
  • Healthy Volunteers
    Accepts Healthy Volunteers
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Objective

The objectives of this study are to (1) test the feasibility of the clinical implementation of preemptive pharmacogenetic (PGx) testing in the emergency department (ED) and (2) determine if PGx testing (with appropriate decision support) decreases ED return visits and hospitalizations. We will conduct a randomized, controlled, pragmatic clinical trial assessing both the real-world effectiveness as well as implementation outcomes using a targeted PGx testing panel in several BOB体育 EDs.

Details

Full study title Trial of Precision Medicine in Emergency Departments
Protocol number OCR45747
ClinicalTrials.gov ID NCT06448091
Phase N/A

Eligibility

Inclusion Criteria:

  1. Adults 40 years or older presenting to a participating ED

  2. Receipt of a new order/prescription for a selected PGx medication (Appendix 1. , with a duration greater than 7 days, during the current ED visit or within 30 days prior.

  3. Documentation of at least 2 prior ED or urgent care visits within the past 12 months

Exclusion Criteria:

  1. Prior clinical pharmacogenetic test results within the EHR for genes relevant for this study (Appendix 1).

  2. History of hepatic or renal transplant

  3. History of severe liver disease (stage Child-Pugh C) or renal disease eGFR

Lead researcher

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  1. Step
    1

    Contact the research team

    Call or email the research team listed within the specific clinical trial or study to let them know that you're interested. A member of the research team, such as the researcher or study coordinator, will be available to tell you more about the study and to answer any questions or concerns you may have.

    Primary contact

  2. Step
    2

    Get screened to confirm eligibility

    You may be asked to take part in prescreening to make sure you are eligible for a study. The prescreening process ensures it is safe for you to participate. During the prescreening process, you will be asked some questions and you may also be asked to schedule tests or procedures to confirm your eligibility.

  3. Step
    3

    Provide your consent to participate

    If you are eligible and want to join the clinical trial or study, a member of the research team will ask for your consent to participate. To give consent, you will be asked to read and sign a consent form for the study. This consent form explains the study's purpose, procedures, risks, benefits and provides other important information, such as the study team's contact information.

  4. Step
    4

    Participate

    If you decide to participate in a clinical trial or study, the research team will keep you informed of the study requirements and what you will need to do to throughout the study. For some trials or studies, your health care provider may work with the research team to ensure there are no conflicts with other medications or treatments.